Born in Iowa, Kacere moved to New York in the early 1950s. He studied at Cooper Union and even though he started as an abstract painter, he moved to a more realistic style during the '60s, beginning his famous series of large paintings.
Although his work can be hyper-realistic, Kacere, unlike photorealistic painters, worked on all areas of the canvas at the same time and building up layers of paint.
Kacere has focused his work in the female body, and despite criticism from feminists, some of whom have labeled his work sexist, Kacere sees the woman as the source of life and praises the aspect of womanhood in each of his works.
Kacere died August 5 of 1999, in Cedar Rapids, Iowa, at the age of 79.